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M9470055.TXT
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1994-07-02
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Document 0055
DOCN M9470055
TI The use of a scanning proton microprobe to observe anti-HIV drugs within
cells.
DT 9409
AU Cholewa M; Legge GJ; Weigold H; Holan G; Birch CJ; Micro Analytical
Research Centre (MARC), School of Physics,; University of Melbourne,
Parkville, Vic., Australia.
SO Life Sci. 1994;54(21):1607-12. Unique Identifier : AIDSLINE MED/94254632
AB A series of inorganic polyanions (viz. heteropolytungstates) has been
shown to have antiviral activity but there was no evidence to indicate
that the drugs reached their site of antiviral (HIV) activity intact. We
have shown that with a scanning proton microprobe it is possible to
analyse the metal content of individual cells (PBLs) treated with such a
polyoxometalate drug and to determine the atomic ratio of the metals
within the cell. This was found to be near that in the drug. The
distribution of the metals (tungsten and cobalt) within the cell was
measured and it was shown that both metals were located in the same
region within the cell. These findings would suggest that the drug had
entered the cells intact.
DE Antiviral Agents/*ANALYSIS/TOXICITY Cells, Cultured
Cobalt/*ANALYSIS/TOXICITY Human HIV/*DRUG EFFECTS
Lymphocytes/*CYTOLOGY Phosphorus/ANALYSIS Phosphotungstic
Acid/*ANALYSIS/TOXICITY Potassium/*ANALYSIS/TOXICITY Spectrometry,
X-Ray Emission/*METHODS Support, Non-U.S. Gov't Tungsten/*ANALYSIS
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).